Seeking to cure his rare blood disorder, Dr. Michael Morbius instead cursed himself with an insatiable lust for human blood. He has become the living vampire.

While trying to cure his horrific condition, he has become allied with Amanda Saint, whose sister Catherine is one of the leaders of the Demon-Fire Cult. Also known as Poison-Lark, Catherine Saint has two goals above all else. She seeks to unleash all the powers of Hell on Earth, and to kill Morbius and Amanda.

Morbius and Amanda follow the cult's trail to New York City, determined to stop Poison-Lark at any cost. But when they run afoul of an underground fight club that uses monsters as their pawns in the arena, Morbius becomes the star attraction, forced to kill or be killed...